Today I was working with several instances of the SalesLogix Administrator, Architect, and Client for an upgrade.  My computer seemed to be running slower than normal, so I did a quick search and found the following things to try.

1. I searched the internet and found out about the prefetch command.  Open Start Menu -> Run -> prefetch.  This opens C:\windows\prefetch\.  I'm not exactly sure what these files do, but it appears you can delete them and Windows will automatically re-create them, which can sometimes help with speed issues.
2. I deleted all of the temporary files in C:\Windows\Temp and  C:\Documents and Settings\username\Local Settings\Temp.
3. I defragmented my hard drive.  After a quick google search, I found that there are many disk defragmenting tools out there.  I used AusLogics Disk Defrag, http://www.auslogics.com/go/diskdefrag/en/software/disk-defrag.

After doing these things my computer appears to have sped up considerably.  Some of these steps may be outside the scope of a normal users day, so I advise consulting with your IT staff before trying any of these options.